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Approximately 15% of the nanoprobe crossed BBB and entered the brain parenchyma, which was much higher than the levels reachable by the traditional pathways 12,13

The Keap 1-Nrf 2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis

This leads to alterations in protein structure and function, such as PKC 74 (Figure 3)

Since the gut is a gateway for environmental pathogens to enter, and the CNS and ENS participate in pathogen resistance mechanisms, the microbial flora and their metabolites are essential for promoting tight-junction expression and maintaining bloodbrain barrier (BBB) function ( Drosophila model of AD (Wu et al., 2017)

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